Veterinarian recommended Petsmile is the first and only toothpaste accepted by the VOHC (Veterinary Oral Health Council) for plaque inhibition, with Calprox. The VOHC with the American Veterinary Dental College recognized that Petsmile meets the highest standards for your pet’s oral health. Petsmile’s proprietary formula Calprox is clinically proven to inhibit plaque and tartar buildup by gently dissolving the protein pellicle. The protein pellicle is the thin bio-film that forms on the surface of the teeth, to which plaque, bacteria, and stains adhere. Removing the pellicle leaves your pet’s teeth cleaner and whiter while improving gum health and providing kissable fresh breath. Petsmile is formulated with human-grade ingredients. It contains calcium, magnesium, phosphates, to re-mineralize and restores enamel. Petsmile is free of animal by-products, BPA, silica, sulfates, parabens, and gluten.